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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Multicopy single-stranded DNA ： ウィキペディア英語版 Multicopy single-stranded DNA Multicopy single-stranded DNA (msDNA) is a type of extrachromosomal satellite DNA that consists of a single-stranded DNA molecule covalently linked via a 2'-5'phosphodiester bond to an internal guanosine of an RNA molecule. The resultant DNA/RNA chimera possesses two stem-loops joined by a branch similar to the branches found in RNA splicing intermediates. The coding region for msDNA, called a "retron", also encodes a type of reverse transcriptase, which is essential for msDNA synthesis. == Discovery == Before the discovery of msDNA in myxobacteria, a group of swarming, soil-dwelling bacteria, it was thought that the enzymes known as reverse transcriptases (RT) existed only in eukaryotes and viruses. The discovery led to an increase in research of the area; as a result, msDNA has been found to be widely distributed among bacteria, including various strains of ''Escherichia coli'' and pathogenic bacteria. Further research discovered similarities between HIV-encoded reverse transcriptase and an open reading frame (ORF) found in the msDNA coding region. Tests confirmed the presence of reverse transcriptase activity in crude lysates of retron-containing strains. Although an RNase H domain was tentatively identified in the retron ORF, it was later found that the RNase H activity required for msDNA synthesis is actually supplied by the host. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Multicopy single-stranded DNA」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.